β-Nicotinamide adenine dinucleotide disodium salt NADH CAS 606-68-851

Product Name:β-Nicotinamide adenine dinucleotide disodium salt NADH CAS 606-68-8
Product Description:
Product Description:
Product Name: β-Nicotinamide adenine dinucleotide disodium salt NADH CAS 606-68-8


Synonyms:
β-Nicotinamide adenine dinucleotide NADH（reduced form）;
NADH disodium salt;
NADH; NADH Reduced form, Disodium;


Chemical & Physical Properties
Appearance : White to Yellowish solid.
Assay : ≥99.0%
Melting point: 140-142℃
Flash Point: 608℃
PH:7.5 (100mg/mL in water, ±0.5)
PSA: 342.90000
LogP: -0.59060
Solubility: H2O: 50 mg/mL, clear to nearly clear, yellow..
Stability: Stable. Incompatible with strong oxidizing agents.
Nicotinamide Adenine Dinucleotide is a water-soluble vitamin, The product is solid, odorless or nearly odorless, bitter in taste, freely soluble in water or ethanol, dissolvable in glycerin.
Category: Enzymes and Coenzymes in Nucleic Acids; Nucleosides and Nucleotides Enzymes, Inhibitors, and Substrates; Pharmaceutical/API Drug Intermediates;


Safety Information
HS Code: 2924199090
Safety Statements: S26; S36/37/39; S45; S24/25; S36/37
WGK Germany:3
Risk Statements:R36/37/38
Hazard Codes: Xn

Storage：Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.


Application:
1. One of the biologically active forms of nicotinic acid. Serves as a coenzyme of hydrogenases and dehydrogenases. NAD usually acts as a hydrogen acceptor, forming NADH which then serves as a hydrogen donor in the respiratory chain. Present in living cells primarily in the reduced form (NADPH) and is involved in synthetic reactions. Occurs in 2 forms, α-NAD and β-NAD, distinguished by the configuration of the ribosyl nicotinamide linkage. Only the β-anomer is bioactive.
2. β- nicotinamide adenine dinucleotide (NAD +) and reduced β - nicotinamide adenine dinucleotide (NADH) constitute a coenzyme redox pair (NAD +: NADH) included in a wide range of enzyme catalyzed redox reactions, as well as its redox function of oxidative chemistry book. In ADP ribosylation (ADP ribosyltransferase, polymerization (ADP ribose polymerase) reaction), it is an ADP- Ribosome donor unit; and a precursor of cyclic ADP ribose (ADP ribosylcyclase).
3. NADH disodium salt is a coenzyme of a large number of oxidoreductases. NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, beta-oxidation and the citric acid cycle.
4. NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. NADH is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage.
5. With good effect for Anti aging , Antioxidant, prevent and treat insomnia, chronic fatigue syndrome, Pakinson's, diabetes Mellitus, senile dementia. etc.


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NADH is synthesized by the body and thus is not an essential nutrient. NADH does require the essential nutrient nicotinamide for its synthesis, and NADH role in energy production is certainly an essential one. In addition to NADH role in the mitochondrial electron transport chain, NADH is produced in the cytosol. The mitochondrial membrane is impermeable to NADH, and this permeability barrier effectively separates the cytoplasmic from the mitochondrial NADH pools. However, cytoplasmic NADH can be used for biologic energy production. This occurs when the malate-aspartate shuttle introduces reducing equivalents from NADH in the cytosol to the electron transport chain of the mitochondria. This shuttle mainly occurs in the liver and heart.

Nicotinamide adenine dinucleotide, abbreviated NADH+, is a coenzyme found in all living cells. The compound is a dinucleotide, since it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base and the other nicotinamide.

In metabolism, NAD+ is involved in redox reactions, carrying electrons from one reaction to another. The coenzyme is, therefore, found in two forms in cells: NAD+ is an oxidizing agent – it accepts electrons from other molecules and becomes reduced. This reaction forms NADH, (Nicotinamide adenine dinucleotide) which can then be used as a reducing agent to donate electrons. These electron transfer reactions are the main function of NAD+. However, it is also used in other cellular processes, the most notable one being a substrate of enzymes that add or remove chemical groups from proteins, in posttranslational modifications. Because of the importance of these functions, the enzymes involved in NAD+ metabolism are targets for drug discovery.

In organisms, NAD+ can be synthesized from simple building-blocks (de novo) from the amino acids tryptophan or aspartic acid. In an alternative fashion, more complex components of the coenzymes are taken up from food as the vitamin called niacin. Similar compounds are released by reactions that break down the structure of NAD+. These preformed components then pass through a salvage pathway that recycles them back into the active form. Some NAD+ is also converted into nicotinamide adenine dinucleotide phosphate (NADP+); the chemistry of this related coenzyme is similar to that of NAD+, but it has different roles in metabolism.


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Company Description
Hefei Home Sunshine Pharmaceutical Technology Co., Ltd
Address:AnHuiAnHuiHeFeiMengcheng1117, Lanchou Mansion, No.135, North Mengcheng Road, 230041, Hefei, Anhui, China
Descption:Hefei Home Sunshine Pharmaceutical Technology Co., Ltd., founded in 2013, is located in Hefei City, China. The company is ISO 9001:2015 certified and mainly engaged in supplying of API (active pharmaceutical ingredients), intermediates and fine chemicals. We regard product quality and credibility as the life of the enterprise.

The management team has more than 15 years of experience in the industry and pays close attention to market dynamics. With a keen sense of market smell, we provide our customers the most professional services and cutting-edge products.
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Hefei Home Sunshine Pharmaceutical Technology Co., Ltd
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